Forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta,9 alpha-trihydroxy-labd-14-ene-11-one) will be the main active component from the Ayurvedic herb Coleus forskohlii. Coleus is part of the mint family and grows in subtropical areas in India, Burma, and Thialand. Forskolin has become extensively researched within the healthcare industry to use in the management of allergies, respiratory problems, cardiovascular diseases, glaucoma, psoriasis, hypothyroidism and weight reduction. Forskolin increases Cyclic AMP and generally seems to have additional actions that are caused by its capability to alter numerous membrane transport proteins.
Increased cellular cyclic AMP brings about inhibition of platelet activation, decreased chance of thrombus, reduced launch of histamine, decreased allergy symptoms, increased force of contraction of the heart, relaxation in the arteries along with other smooth muscles, increased thyroid function, increased fat metabolism, increased energy and possibly weight-loss. Cyclic AMP as well as the chemicals it activates comprise an additional messenger system that is mainly responsible for doing the complex and powerful effects of hormones in your body.
Glaucoma is really a condition when the pressure within the eye is just too high, as a result of an imbalance between your formation of aqueous humor inside the eye and its absorption in or drainage out from the eye. Eventually, as the pressure builds, the blood vessels nourishing the optic nerve are constricted, contributing to irreversible harm to the nerve and impaired vision culminating in blindness, if left unattended.
While you can find no tried and tested alternative therapies for glaucoma, there are many treatments which may be beneficial and coleus is one of them. Clinical studies show that topical application of one percent forskolin for high blood pressure contributed to significant decreases in intraocular pressure for as much as five hours. Limited clinical experience demonstrates that oral forskolin seems to offer significant potential for people with glaucoma. An Indian pharmaceutical company is currently engaged in clinical trials of any forskolin eye drop product.
Depression is believed to be connected with an imbalance of neurotransmitters from the brain, serotonin and dopamine primarily. Where you will discover a shortage of serotonin, the supplements 5-HTP or tryptophan or perhaps the SSRI drugs like prozac or Zoloft could be beneficial. If the catecholamine neurotransmitters (epinephrine, norephinephrine) are deficient the amino acids L-Phenylalanine or L-Tyrosine, or monoamine oxidase inhibitors like GeroVital (GH3) or Deprenyl are can be helpful. Recent research has been evaluating drugs that increase Cyclic AMP as a way of elevating the catecholamines. Since forskolin elevates Cyclic AMP, it could improve neurotransmitter function and thereby relieve depression. Numerous studies using coleus to treat depression have not been done.
Coleus is an excellent smooth muscle relaxer, contributing to bronchodilation, decreased airway resistance, increased vital capacity and increased forced expiratory volume. This action is the effect of the increase in Cyclic AMP a result of coleus. Many asthma medications increase Cyclic AMP by inhibiting the enzymes that cause 62dexppky breakdown. Thus, coleus along with the traditional asthma drugs will likely act synergistically. Therefore, you should consult their physician before combining them.
In vitro (studies completed in the lab) research shows that coleus stimulates fat metabolism. Researchers have learned that many obese people have below normal Cyclic AMP production. Because of these considerations, coleus may, theoretically, be a fat loss agent, especially for those with reduced Cyclic AMP production. In research conducted recently, six overweight women took 25 mg of coleus (250 mg capsules of 10% standardized forskolin extract) two times a day for eight weeks. After the eight-week trial, the participants lost a mean of ten pounds, and reduced their portion of extra fat by nearly 8%. Blood pressure levels levels also trended lower during the trial.
Forskolin has demonstrated the ability to increase thyroid hormone production and stimulate thyroid hormone release.
Reserch has shown coleus to be a potent inhibitor of tumor colonization in mice. It is theoretically probable that coleus could possibly be found in humans to avoid or inhibit tumor metastases.
Forskolin generally seems to exhibit potent immunity mechanism enhancement by activating macrophages and lymphocytes.
Coleus forskohlii has traditionally been employed to treat hypertension, congestive heart failure, and angina. Coleus’s basic cardiovascular action is usually to lower blood pressure level, while simultaneously enhancing the contractility of the heart. This is thought to be on account of forskolin’s Cyclic AMP-elevating ability, which results in relaxation in the arteries, and increased force of contraction of your heart muscle. A preliminary trial learned that coleus reduced blood pressure levels and improved heart function in people with cardiomyopathy. Coleus also increases cerebral blood flow, indicating that it could be advantageous in cerebral vascular insufficiency, as well as in enhancing post-stroke recovery. The platelet aggregation-inhibiting results of coleus also contributes to its value in cardiovascular disorders.
There exists some evidence that forskolin may boost the outcomes of beta-agonists like albuterol. Forskolin can also act synergistically with epinephrine, ephedrine and pseudoephedrine. It is likely that the usage of forskolin may lessen the needed dosages of beta-agonists. Anyone taking these drugs should consult their physician if they want to also use forskolin.
Because forskolin inhibits platelet aggregation and clotting, it may enhance the results of anti-clotting medications including warfarin, clopidogre, aspirin, enoxaparin, and dalteparin. Anyone taking any anti-clotting medications or supplements should consult their physician before adding forskolin to their regimen.
There is certainly limited information from clinical studies about the secure and efficient dosages of forskolin. In line with the human studies to lose weight, 50 to 100 mg of forskolin consumed divided doses during the day is apparently an appropriate dose to the conditions discussed above.